The Placental Effect
As the placenta grows, it secretes hormones like human placental lactogen (hPL) and cortisol. While essential for fetal development, these hormones create a state of insulin resistance in the mother's body, meaning her pancreas must work up to three times harder to clear glucose from the blood.
Insulin resistance is a normal biological adaptation in pregnancy to ensure the baby gets enough glucose. GDM simply means the pancreas couldn't keep up with the increased demand.